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T-type Ca2+ channels are involved in high glucose-induced rat neonatal cardiomyocyte proliferation.

Published on Apr 1, 2005in Pediatric Research 2.88
· DOI :10.1203/01.PDR.0000155756.89681.3C
Ming Li23
Estimated H-index: 23
,
Min Zhang7
Estimated H-index: 7
+ 5 AuthorsRichard M Whitehurst6
Estimated H-index: 6
Cite
Abstract
T-Type Ca 2+ Channels Are Involved in High Glucose–Induced Rat Neonatal Cardiomyocyte Proliferation
  • References (35)
  • Citations (38)
Cite
References35
Newest
Published on Dec 12, 2003in Circulation Research 15.86
Laurent Ferron11
Estimated H-index: 11
,
Véronique Capuano2
Estimated H-index: 2
+ 3 AuthorsJean-François Renaud11
Estimated H-index: 11
Recent studies indicate that cardiac T-type Ca 2+ current ( I CaT ) reappears in hypertrophied ventricular cells. The aim of this study was to investigate the role of angiotensin II (Ang II), a major inducer of cardiac hypertrophy, in the reexpression of T-type channel in left ventricular hypertrophied myocytes. We induced cardiac hypertrophy in rats by abdominal aorta stenosis for 12 weeks and thereafter animals were treated for 2 weeks with losartan (12 mg/kg per day), an antagonist of type 1 ...
Published on Nov 18, 2003in Circulation 23.05
Toshiaki Izumi9
Estimated H-index: 9
(Kyoto University),
Yasuki Kihara40
Estimated H-index: 40
(Kyoto University)
+ 7 AuthorsAkinori Noma37
Estimated H-index: 37
(Kyoto University)
Background— In ventricular myocardium, the T-type Ca2+ current (ICa,T), which is temporarily observed during fetal and neonatal periods, has been shown to reappear in failing/remodeling hearts. However, its pathophysiological regulation has not been elucidated. Methods and Results— We utilized Dahl salt-sensitive (DS) rats with hypertension at the stage of concentric left ventricular (LV) hypertrophy (11 weeks old, LVH) and at the heart failure stage (16 to 18 weeks old, CHF). Some were treated ...
Published on Aug 1, 2001in Toxicology in Vitro 3.07
G. Repetto19
Estimated H-index: 19
,
A. del Peso6
Estimated H-index: 6
+ 1 AuthorsM. Repetto19
Estimated H-index: 19
Lithium and nickel present low toxicity, but are able to cause alterations in different tissues. The toxic effects of lithium and nickel at different cellular levels were assessed using two inorganic chemical species: lithium chloride and nickel(II) chloride. Mouse neuroblastoma cell cultures (Neuro-2a) were exposed to both compounds for 24 h. The cytotoxic effects evaluated were cell proliferation by quantification of total protein content, cytoplasmic membrane integrity to cytosolic lactate de...
Published on Jul 1, 2001in Journal of Molecular and Cellular Cardiology 5.05
Caroline Pascarel6
Estimated H-index: 6
,
Fabien Brette11
Estimated H-index: 11
(University of Leeds),
Jean Yves Le Guennec3
Estimated H-index: 3
Abstract C. Pascarel, F. Brette and J.-Y. Le Guennec. Enhancement of the T-type Calcium Current by Hyposmotic Shock in Isolated Guinea-pig Ventricular Myocytes. Journal of Molecular and Cellular Cardiology (2001) 33 , 0000–0000. It is known that swelling and shrinkage of cardiac cells can modulate their electrical activity. However, the effects of osmotic manipulation on cardiac T-type calcium current (I CaT ) has not been previously reported. In this study, we have examined the effects of cell ...
Published on Mar 2, 2001in Circulation Research 15.86
Leanne L. Cribbs33
Estimated H-index: 33
,
Beverly L. Martin2
Estimated H-index: 2
+ 3 AuthorsJonathan Satin25
Estimated H-index: 25
Abstract—During cardiac development, there is a reciprocal relationship between cardiac morphogenesis and force production (contractility). In the early embryonic myocardium, the sarcoplasmic reticulum is poorly developed, and plasma membrane calcium (Ca2+) channels are critical for maintaining both contractility and excitability. In the present study, we identified the CaV3.1d mRNA expressed in embryonic day 14 (E14) mouse heart. CaV3.1d is a splice variant of the α1G, T-type Ca2+ channel. Immu...
Published on Feb 1, 2001in The International Journal of Biochemistry & Cell Biology 3.14
Renuka R. Nair5
Estimated H-index: 5
,
Preetha Nair3
Estimated H-index: 3
Abstract This study was designed to examine the influence of the age of adults on the contractile characteristics of the myocardium and to ascertain whether the age dependent variation is related to variation in sarcolemmal calcium channels. Cardiomyocytes were isolated from 2, 6 and 12-month-old, male Sprague–Dawley rats and the extent and velocity of contraction were recorded as a function of change in cell length. Age dependent increase in cell length and sarcomere length was significant ( P ...
Published on Jan 1, 2000in Diabetes 7.20
Hean Zhuang4
Estimated H-index: 4
,
Arin Bhattacharjee22
Estimated H-index: 22
+ 6 AuthorsMing Li23
Estimated H-index: 23
The T-type Ca2+ channel is an important determinant of electrical activity and of Ca2+ influx in rat and human pancreatic beta-cells. We have identified and sequenced a cDNA encoding a T-type Ca2+ channel alpha1-subunit derived from INS-1, the rat insulin-secreting cell line. The sequence of the cDNA indicates a protein composed of 2,288 amino acids that shares 96.3% identity to alpha1G, the neuronal T-type Ca2+ channel subunit. The transmembrane domains of the protein are highly conserved, but ...
Published on Jan 1, 2000in Neuroimmunomodulation 1.35
Edward Baral13
Estimated H-index: 13
,
Eva Nagy22
Estimated H-index: 22
+ 3 AuthorsIstvan Berczi32
Estimated H-index: 32
The effect of tamoxifen (TX; 1.0 μ M ) on the mitogenic response of rat lymphocytes was compared with the effect of drugs that are known to act on protein kinase C (PKC), calmodulin (
Published on Dec 1, 1999in Biophysical Journal 3.67
Jung-Ha Lee9
Estimated H-index: 9
(Loyola University Medical Center),
Juan Carlos Gomora2
Estimated H-index: 2
(Loyola University Medical Center)
+ 1 AuthorsEdward Perez-Reyes57
Estimated H-index: 57
(Loyola University Medical Center)
Nickel has been proposed to be a selective blocker of low-voltage-activated, T-type calcium channels. However, studies on cloned high-voltage-activated Ca(2+) channels indicated that some subtypes, such as alpha1E, are also blocked by low micromolar concentrations of NiCl(2). There are considerable differences in the sensitivity to Ni(2+) among native T-type currents, leading to the hypothesis that there may be more than one T-type channel. We confirmed part of this hypothesis by cloning three n...
Published on Dec 1, 1999in Biochimica et Biophysica Acta 3.79
Keiko Akagi4
Estimated H-index: 4
(UTokyo: University of Tokyo),
Taku Nagao35
Estimated H-index: 35
(UTokyo: University of Tokyo),
Tetsuro Urushidani12
Estimated H-index: 12
(UTokyo: University of Tokyo)
Abstract Gastrin stimulates cell proliferation through the CCK B receptor coupled to Gq-protein, whereas the m3 muscarinic receptor, which also couples to Gq, has no trophic effects. In order to elucidate the cause of the difference, we stably transfected CHO cells with human CCK B and m3 receptors. Stimulation of the CCK B , but not the m3 receptor increased cell growth. Activation of MAP kinase via the m3 receptor was to the same extent as that via CCK B , indicating that there is an initial s...
Cited By38
Newest
Published on Apr 1, 2019in Trends in Molecular Medicine 11.03
Anna Visa2
Estimated H-index: 2
,
Soni Shaikh1
Estimated H-index: 1
+ 2 AuthorsCarles Cantí Nicolás7
Estimated H-index: 7
T-Type calcium channels (TTCCs) are key regulators of membrane excitability, which is the reason why TTCC pharmacology is subject to intensive research in the neurological and cardiovascular fields. TTCCs also play a role in cancer physiology, and pharmacological blockers such as tetralols and dihydroquinazolines (DHQs) reduce the viability of cancer cells in vitro and slow tumor growth in murine xenografts. However, the available compounds are better suited to blocking TTCCs in excitable membra...
Published on Dec 1, 2017in The Journal of Steroid Biochemistry and Molecular Biology 3.79
D. Falcón1
Estimated H-index: 1
(University of Seville),
R. González-Montelongo (University of Seville)+ 3 AuthorsAntonio Castellano19
Estimated H-index: 19
(University of Seville)
Abstract Glucocorticoids are widely used to treat acute and chronic diseases. Unfortunately, their therapeutic use is associated with severe side effects. Glucocorticoids are known to regulate several ion channels in cardiac myocytes, including voltage-dependent Ca 2+ channels. Low-voltage-activated T-type Ca 2+ channels are expressed in ventricular myocytes during the fetal and perinatal period, but are practically absent in the adult. However, these channels can be re-expressed in adult cardio...
Published on Apr 1, 2016in Journal of Pharmacy and Pharmacology 2.39
Firouzeh Asadi3
Estimated H-index: 3
(IUMS: Iran University of Medical Sciences),
Ali Razmi6
Estimated H-index: 6
+ 1 AuthorsMassoumeh Shafiei11
Estimated H-index: 11
(IUMS: Iran University of Medical Sciences)
Objectives Cardiomyocyte hypertrophy is an important structural feature of diabetic cardiomyopathy. Calcineurin/nuclear factor of activated T-cell (NFAT) pathway plays a central role in the pathogenesis of cardiac hypertrophy. The purpose of this study was to investigate the effects of tropisetron, a novel calcineurin inhibitor, on high glucose (HG)-induced cardiomyocyte hypertrophy and its underlying mechanism. Methods H9c2 myocardial cells were treated with tropisetron or cyclosporine A 1 h be...
Published on Feb 1, 2016in Toxicology Letters 3.50
Wesley W. Holmes9
Estimated H-index: 9
,
Brian Keyser6
Estimated H-index: 6
+ 8 AuthorsAlfred M. Sciuto7
Estimated H-index: 7
Abstract Toxic industrial chemicals are used throughout the world to produce everyday products such as household and commercial cleaners, disinfectants, pesticides, pharmaceuticals, plastics, paper, and fertilizers. These chemicals are produced, stored, and transported in large quantities, which poses a threat to the local civilian population in cases of accidental or intentional release. Several of these chemicals have no known medical countermeasures for their toxic effects. Phosgene is a high...
Published on Apr 1, 2015in Journal of Occupational and Environmental Medicine 1.59
Jason Y.Y. Wong15
Estimated H-index: 15
,
Shona C. Fang19
Estimated H-index: 19
+ 2 AuthorsDavid C. Christiani83
Estimated H-index: 83
Background The objective of this study was to evaluate the relationship between cumulative occupational exposure to various metals and arterial compliance in welders.
Published on Jan 1, 2015
Ming Li (Tulane University)
Increases in plasma glucose concentration enhance the expression and activity of T-type Ca2+ channels in insulin-secreting pancreatic β-cells. The resulting elevation in T-type Ca2+ channel activity results in an elevation in the basal [Ca2+]i of β-cells. High [Ca2+]i in turn causes the internalization of L-type Ca2+ channels from cytoplasmic membrane, which contributes to glucose toxicity in β-cells. Increased activity of T-type Ca2+ channels, along with elevated [Ca2+]i, promotes low threshold...
Published on Jan 1, 2015
Ming Li (Tulane University), Songwei Wu (Georgia Regents University)
T-type Ca2+ channels play many important physiological functions in different tissues; this makes the channels targets for extracellular and intracellular regulation. T-type Ca2+ channels in many non-excitable cells provide an essential mechanism for Ca2+ entry at voltages near the resting membrane potential, which revises the homeostasis of the intracellular Ca2+ concentration to promote cell cycling and cell duplication. Consistent with this function, many of the extracellular signals stimulat...
Published on Jan 1, 2015
Jonathan E. Pottle3
Estimated H-index: 3
(Tulane University),
Lloyd S. Gray20
Estimated H-index: 20
Calcium signaling plays an important role in the regulation of cell cycling. Cells passing from G1 to S require both extracellular calcium and functional plasma membrane calcium channels in order to activate various downstream enzymes, such as ribonucleotide reductase, thymidine kinase, thymidylate synthase, and DNA polymerase. Fast proliferating cancer cells contain higher levels of basal [Ca2+]i than normal epithelial cells. Indeed, in order to compensate for the increased requirement for Ca2+...
Published on Nov 1, 2014in Cell Calcium 3.93
Guillermo Avila16
Estimated H-index: 16
(CINVESTAV),
Diana Stephanie Osornio-Garduño2
Estimated H-index: 2
(CINVESTAV)
+ 1 AuthorsRoberto Ramos-Mondragón6
Estimated H-index: 6
(CINVESTAV)
Abstract A synthetic compound, termed pirfenidone (PFD), is considered promising for the treatment of cardiac disease. It leads to beneficial effects in animal models of diabetes mellitus (DM); as well as in heart attack, atrial fibrillation, muscular dystrophy, and diabetic cardiomyopathy (DC). The latter is a result of alterations linked to metabolic syndrome as they promote cardiac hypertrophy, fibrosis and contractile dysfunction. Although reduced level of fibrosis and stiffness represent an...