Min Zhang
University of South Alabama
Publications 8
#1Ming LiH-Index: 24
#2Min ZhangH-Index: 7
Last.Richard M WhitehurstH-Index: 6
view all 8 authors...
T-Type Ca 2+ Channels Are Involved in High Glucose–Induced Rat Neonatal Cardiomyocyte Proliferation
39 CitationsSource
Mibefradil is a Ca 2+ channel antagonist that inhibits both T-type and high-voltage-activated Ca 2+ channels. We previously showed that block of high-voltage-activated channels by mibefradil occurs through the production of an active metabolite by intracellular hydrolysis. In the present study, we modified the structure of mibefradil to develop a nonhydrolyzable analog, (1 S , 2 S )-2-(2-( N -[(3-benzimidazol-2-yl)propyl]- N -methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl c...
133 CitationsSource
Chronic exposure of pancreatic β-cells to high concentrations of glucose impairs the insulin secretory response to further glucose stimulation. This phenomenon is referred to as glucose desensitization. It has been shown that glucose desensitization is associated with abnormal elevation of β-cell basal intracellular free Ca2+ concentration ([Ca2+]i). We have investigated the relationship between the basal intracellular free Ca2+ and the L-type (Cav1.3) Ca2+ channel translocation in insulin-secre...
21 CitationsSource
It has been shown that mibefradil (Ro 40-5967) exerts a selective inhibitory effect on T-type Ca2+ currents, although at higher concentrations it can antagonize high voltage-activated Ca2+ currents. The action of mibefradil on Ca2+channels is use- and steady-state-dependent and the binding site of mibefradil on L-type Ca2+ channels is different from that of dihydropyridines. By using conventional whole-cell and perforated patch-clamp techniques, we showed that mibefradil has an inhibitory effect...
37 Citations
#1Hean ZhuangH-Index: 4
#2Arin BhattacharjeeH-Index: 22
Last.Ming LiH-Index: 24
view all 9 authors...
The T-type Ca2+ channel is an important determinant of electrical activity and of Ca2+ influx in rat and human pancreatic beta-cells. We have identified and sequenced a cDNA encoding a T-type Ca2+ channel alpha1-subunit derived from INS-1, the rat insulin-secreting cell line. The sequence of the cDNA indicates a protein composed of 2,288 amino acids that shares 96.3% identity to alpha1G, the neuronal T-type Ca2+ channel subunit. The transmembrane domains of the protein are highly conserved, but ...
42 CitationsSource
#1Richard M Whitehurst (USA: University of South Alabama)H-Index: 6
#2Min Zhang (USA: University of South Alabama)H-Index: 7
Last.Ming Li (USA: University of South Alabama)H-Index: 24
view all 4 authors...
Abstract The mechanism responsible for dexamethasone-induced hypertrophy in infants has not been defined. In this study, we have investigated the role of l -type Ca 2+ currents in the development of dexamethasone-induced hypertrophy in rat neonatal cardiac myocytes. Using cytoplasmic membrane capacitance measurements, we have shown that the size of the cells treated with dexamethasone were larger than those of the control cells. In addition, treating the cells with 1 μ mdexamethasone for 48 h in...
44 CitationsSource
#1Min ZhangH-Index: 7
#2Hean ZhuangH-Index: 4
Last.Richard M WhitehurstH-Index: 6
view all 5 authors...
High Glucose Increases [Ca 2+ ] i through an Increased Expression of T-Type Ca 2+ Channels in Neonatal Rat Cardiomyocytes
#1Arin Bhattacharjee (USA: University of South Alabama)H-Index: 22
#2Richard M Whitehurst (USA: University of South Alabama)H-Index: 6
Last.Ming Li (USA: University of South Alabama)H-Index: 24
view all 5 authors...
The present study addresses the function of T-type voltage-gated calcium channels in insulin-secreting cells. We used whole-cell voltage and current recordings, capacitance measurements, and RIA techniques to determine the contribution of T-type calcium channels in modulation of electrical activity and in stimulus-secretion coupling in a rat insulin secreting cell line, INS-1. By employing a double pulse protocol in the current-clamp mode, we found that activation of T-type calcium channels prov...
66 CitationsSource