Analysis of cytokine gene expression in squamous cell carcinoma of the head and neck

Cytokine production in squamous cell carcinoma (SCC) of the head and neck may directly influence the clinical behavior of this aggressive neoplasm since cytokines act as autocrine/paracrine growth factors, as well as immunomodulators. In the present study, the cytokine profiles of 16 SCCs of the head and neck and matched autologous, noncancerous mucosa were determined and compared to normal oral mucosa. Cytokine gene expression in noncancerous...