Original paper
Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation
Abstract
Cytosine residues in mammalian DNA occur in at least three forms, cytosine (C), 5-methylcytosine (M; 5mC) and 5-hydroxymethylcytosine (H; 5hmC). During semi-conservative DNA replication, hemi-methylated (M/C) and hemi-hydroxymethylated (H/C) CpG dinucleotides are transiently generated, where only the parental strand is modified and the daughter strand contains native cytosine. Here, we explore the role of DNA methyltransferases (DNMT) and ten...
Paper Details
Title
Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation
Published Date
Feb 22, 2012
Journal
Volume
40
Issue
11
Pages
4841 - 4849
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Notes
History