Characterization of disease-associated single amino acid polymorphisms in terms of sequence and structure properties 1 1Edited by J. Thornton
Abstract
In the present work, we use structural information to characterize a set of disease-associated single amino acid polymorphisms exhaustively. The analysis of different properties, such as substitution matrix elements, secondary structure, accessibility, free energies of transfer from water to octanol, amino acid volume, etc., suggests that many disease-causing mutations are associated with extreme changes in the value of parameters relating to...
Paper Details
Title
Characterization of disease-associated single amino acid polymorphisms in terms of sequence and structure properties 1 1Edited by J. Thornton
Published Date
Jan 1, 2002
Journal
Volume
315
Issue
4
Pages
771 - 786
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