Roles of Molecular Regions in Determining Differences between Voltage Dependence of Activation of CaV3.1 and CaV1.2 Calcium Channels

Voltage-dependent calcium channels are classified into low voltage-activated and high voltage-activated channels. We have investigated the molecular basis for this difference in voltage dependence of activation by constructing chimeras between a low voltage-activated channel (CaV3.1) and a high voltage-activated channel (CaV1.2), focusing on steady-state activation properties. Wild type and chimeras were expressed in oocytes, and two-electrode...