Original paper
DNA damage response – A double-edged sword in cancer prevention and cancer therapy
Abstract
Genomic stability depends on an efficient DNA damage repair system to keep the chromosomes intact. Unrepaired DNA damage not only causes cell cycle arrest, apoptosis, but also accumulates genome mutations. DNA damage response (DDR) exhibits a critical function on the protection against human cancer, as indicated by the high predisposition to cancer of individuals with germ-line mutations in DDR genes. However, a defective DNA repair is liked...
Paper Details
Title
DNA damage response – A double-edged sword in cancer prevention and cancer therapy
Published Date
Mar 1, 2015
Journal
Volume
358
Issue
1
Pages
8 - 16
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Notes
History