Original paper
Novel reporter systems for facile evaluation of I-SceI-mediated genome editing
Abstract
Two major limitations to achieve efficient homing endonuclease-stimulated gene correction using retroviral vectors are low frequency of gene targeting and random integration of the targeting vectors. To overcome these issues, we developed a reporter system for quick and facile testing of novel strategies to promote the selection of cells that undergo targeted gene repair and to minimize the persistence of random integrations and non-homologous...
Paper Details
Title
Novel reporter systems for facile evaluation of I-SceI-mediated genome editing
Published Date
Nov 21, 2011
Journal
Volume
40
Issue
2
Pages
e14 - e14
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Notes
History