Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy
Abstract
Oxidative stress and mitochondrial failure are prominent factors in the axonal degeneration process. In this study, we demonstrate that sirtuin 1 (SIRT1), a key regulator of the mitochondrial function, is impaired in the axonopathy and peroxisomal disease X-linked adrenoleukodystrophy (X-ALD). We have restored SIRT1 activity using a dual strategy of resveratrol treatment or by the moderate transgenic overexpression of SIRT1 in a X-ALD mouse...
Paper Details
Title
Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy
Published Date
Mar 27, 2015
Journal
Volume
22
Issue
11
Pages
1742 - 1753
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Notes
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