von Willebrand factor propeptide and the phenotypic classification of von Willebrand disease

The ratios between von Willebrand factor propeptide (VWFpp) or factor VIII activity (C) and VWF antigen (VWF:Ag) reflect synthesis, secretion, and clearance of VWF. We aimed to define the pathophysiology of 658 patients with type 1, 2, or 3 von Willebrand disease (VWD) with VWF levels ≤30 U/dL from the Willebrand in The Netherlands (WiN) study using the VWFpp/VWF:Ag andC/VWF:Ag ratios. We evaluated the use of VWFpp in the classification and...