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Dafna Groeneveld
Michigan State University
18Publications
8H-index
227Citations
Publications 18
Newest
#1Dafna Groeneveld (MSU: Michigan State University)H-Index: 8
#2Holly Cline-Fedewa (MSU: Michigan State University)H-Index: 3
Last.James P. Luyendyk (MSU: Michigan State University)H-Index: 30
view all 9 authors...
Abstract Background & Aim Acetaminophen (APAP)-induced acute liver failure is associated with substantial alterations in the hemostatic system. In mice, platelets accumulate in the liver after APAP overdose and appear to promote liver injury. Interestingly, patients with acute liver injury have highly elevated levels of the platelet-adhesive protein von Willebrand factor (VWF), but a mechanistic connection between VWF and progression of liver injury has not been established. We tested the hypoth...
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#1Dafna Groeneveld (MSU: Michigan State University)H-Index: 8
#2James P. Luyendyk (MSU: Michigan State University)H-Index: 30
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#1Dafna GroeneveldH-Index: 8
#2Holly Cline-FedewaH-Index: 3
Last.James P. LuyendykH-Index: 30
view all 9 authors...
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#1Dafna Groeneveld (MSU: Michigan State University)H-Index: 8
#2David Pereyra (Medical University of Vienna)H-Index: 5
Last.James P. Luyendyk (MSU: Michigan State University)H-Index: 30
view all 9 authors...
Platelets play a pivotal role in stimulating liver regeneration after partial hepatectomy in rodents and humans. Liver regeneration in rodents is delayed when platelets are inhibited. However, the exact mechanisms whereby platelets accumulate and promote liver regeneration remain uncertain. Thrombin-dependent intrahepatic fibrin(ogen) deposition was recently reported after partial hepatectomy (PHx) in mice, but the role of fibrin(ogen) deposits in liver regeneration has not been investigated. We...
6 CitationsSource
#1Dafna GroeneveldH-Index: 8
#2Y. V. Sanders (Erasmus University Medical Center)H-Index: 6
Last.Frank W.G. Leebeek (Erasmus University Medical Center)H-Index: 46
view all 12 authors...
Inhibition of von Willebrand factor (VWF) expression in endothelial cells results in enhanced, possible dysfunctional angiogenesis, consistent with observations of severe gastrointestinal bleedings caused by vascular malformations in patients with von Willebrand disease (VWD). VWF is stored in endothelial Weibel–Palade bodies (WPB) with several other mediators of angiogenesis, like angiopoietin-2, osteoprotegerin and galectin-3. Increased release of angiopoietin-2 has been observed in medium of ...
4 CitationsSource
#1Nikita Joshi (MSU: Michigan State University)H-Index: 9
#2Anna K. Kopec (MSU: Michigan State University)H-Index: 14
Last.James P. LuyendykH-Index: 30
view all 7 authors...
Abstract Liver diseases are associated with complex changes in the hemostatic system and elevated levels of the platelet-adhesive protein Von Willebrand factor (VWF) are reported in patients with acute and chronic liver damage. Although elevated levels of VWF are associated with fibrosis in the general population, the role of VWF in acute and chronic liver injury has not been examined in depth in experimental settings. We tested the hypothesis that VWF deficiency inhibits experimental liver inju...
3 CitationsSource
#1Dafna Groeneveld (UG: University of Groningen)H-Index: 8
#2Edris M. Alkozai (UG: University of Groningen)H-Index: 7
Last.Ton Lisman (UG: University of Groningen)H-Index: 51
view all 5 authors...
BACKGROUND: Conventional coagulation tests are frequently prolonged after liver surgery, suggesting a postoperative bleeding tendency. At the same time, thrombotic complications following partial hepatectomy (PH) are not uncommon. Little is known about changes in the platelet adhesive protein von Willebrand factor (VWF) and its cleaving protease a disintegrin and metalloprotease with a thrombospondin type 1 motif, member 13 (ADAMTS13) following a PH. METHODS: Plasma samples were collected before...
11 CitationsSource
#1Dafna Groeneveld (UMCG: University Medical Center Groningen)H-Index: 8
#2Jelle Adelmeijer (UMCG: University Medical Center Groningen)H-Index: 24
Last.Ton LismanH-Index: 51
view all 6 authors...
BACKGROUND: Optimal hemostatic management during orthotopic liver transplantation (OLT) remains a challenge. The cause of bleeding during OLT is multifactorial, and may include hemostatic imbalance. Fibrinogen concentrates are increasingly being used to control perioperative bleeding during OLT. However, administration is based on arbitrary thresholds of fibrinogen levels. Importantly, studies on fibrin clot structure during OLT are lacking. OBJECTIVE: We determined the hemostatic efficacy of fi...
11 CitationsSource
#1Dafna Groeneveld (LUMC: Leiden University Medical Center)H-Index: 8
#2T. van Bekkum (LUMC: Leiden University Medical Center)H-Index: 2
Last.Jeroen C. J. Eikenboom (LUMC: Leiden University Medical Center)H-Index: 45
view all 7 authors...
BACKGROUND: Endothelial von Willebrand factor (VWF) inhibits angiogenesis. Accordingly, blood outgrowth endothelial cells (BOECs) isolated from von Willebrand disease (VWD) patients showed enhanced in vitro angiogenesis when compared with healthy control BOECs. Characterization of the angiogenic response of VWD BOECs is limited and differences between the different types of VWD have not been investigated in detail. OBJECTIVES: The aim of this study was to further explore the potential pathogenic...
15 CitationsSource
#1Y. V. Sanders (Erasmus University Medical Center)H-Index: 6
#2Dafna Groeneveld (LUMC: Leiden University Medical Center)H-Index: 8
Last.Jeroen C. J. Eikenboom (LUMC: Leiden University Medical Center)H-Index: 45
view all 12 authors...
The ratios between von Willebrand factor propeptide (VWFpp) or FVIII coagulant activity (FVIII:C) and VWF antigen (VWF:Ag) reflect synthesis, secretion and clearance of VWF. We aimed to define the pathophysiology of 658 types 1, 2 and 3 von Willebrand disease (VWD) patients with VWF levels ≤30 U/dL from the "Willebrand in the Netherlands" (WiN-)study using the VWFpp/VWF:Ag and FVIII:C/VWF:Ag ratios. We also evaluated the use of VWFpp in the classification and diagnosis of VWD. Based on the ratio...
27 CitationsSource
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