Corticosterone-Induced Insulin Resistance Is Not Associated with Alterations of Insulin Receptor Number and Kinase Activity in Chicken Kidney

Chicken renal insulin receptors have been recently characterized; their number and kinase activities vary in response to altered nutritional status. In the present study, the effect of chronic corticosterone treatment was examined in 5-week-old chickens. The development of an insulin resistance following corticosterone was suggested after 1 and 2 weeks of treatment by a significant decrease in the hypoglycemic effect of exogenous insulin and...