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Rationale and design of a randomized clinical trial of β-blocker therapy (atenolol) versus angiotensin II receptor blocker therapy (losartan) in individuals with Marfan syndrome

Published on Oct 1, 2007in American Heart Journal4.02
· DOI :10.1016/j.ahj.2007.06.024
Ronald V. Lacro28
Estimated H-index: 28
(Harvard University),
Harry C. Dietz86
Estimated H-index: 86
(Johns Hopkins University)
+ 15 AuthorsLynn Mahony30
Estimated H-index: 30
(UTSW: University of Texas Southwestern Medical Center)
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Abstract
Background Cardiovascular disease, including aortic root dilation, dissection, and rupture, is the leading cause of mortality in patients with Marfan syndrome (MFS). The maximal aortic root diameter at the sinuses of Valsalva is considered the best predictor of adverse cardiovascular outcome. Although advances in therapy have improved life expectancy, affected individuals continue to suffer cardiovascular morbidity and mortality. Recent studies in an FBN1 -targeted mouse model of MFS with aortic disease similar to that seen in humans showed that treatment with losartan normalized aortic root growth and aortic wall architecture. Methods The Pediatric Heart Network designed a randomized clinical trial to compare aortic root growth and other short-term cardiovascular outcomes in subjects with MFS receiving atenolol or losartan. Individuals 6 months to 25 years of age with a body surface area–adjusted aortic root z score >3.0 will be eligible for inclusion. The primary aim is to compare the effect of atenolol therapy with that of losartan therapy on the rate of aortic root growth over 3 years. Secondary end points include progression of aortic regurgitation; incidence of aortic dissection, aortic root surgery, and death; progression of mitral regurgitation; left ventricular size and function; echocardiographically derived measures of central aortic stiffness; skeletal and somatic growth; and incidence of adverse drug reactions. Conclusion This randomized trial should make a substantial contribution to the management of individuals with MFS and expand our understanding of the mechanisms responsible for the aortic manifestations of this disorder.
  • References (34)
  • Citations (194)
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References34
Newest
#1Lynn Mahony (UTSW: University of Texas Southwestern Medical Center)H-Index: 30
#2Lynn A. SleeperH-Index: 69
Last.G. D. Pearson (UTSW: University of Texas Southwestern Medical Center)H-Index: 1
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#1Daniel P. Judge (Johns Hopkins University)H-Index: 39
#2Harry C. Dietz (Johns Hopkins University)H-Index: 86
#1Angela T Yetman (Anschutz Medical Campus)H-Index: 8
#2Renee A. Bornemeier (University of Arkansas for Medical Sciences)H-Index: 9
Last.Brian W. McCrindle (U of T: University of Toronto)H-Index: 86
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#1Bart Loeys (Johns Hopkins University)H-Index: 56
#2Junji Chen (Johns Hopkins University)H-Index: 1
Last.Neda Sharifi (Johns Hopkins University)H-Index: 2
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#2Nan M. LairdH-Index: 97
Last.James H. Ware (Harvard University)H-Index: 73
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#1Fabian Emrich (Stanford University)H-Index: 8
#2Kiril Penov (Stanford University)H-Index: 5
Last.Andrew J. Connolly (Stanford University)H-Index: 39
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#2Kim A. Eagle (UM: University of Michigan)H-Index: 115
Last.Dianna M. Milewicz (University of Texas Health Science Center at Houston)H-Index: 56
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#1Alan C. Braverman (WashU: Washington University in St. Louis)H-Index: 23
#1Arvind Hoskoppal (UofU: University of Utah)H-Index: 1
#2Shaji C. Menon (UofU: University of Utah)H-Index: 17
Last.Wyman W. Lai (Columbia University)H-Index: 9
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#1Douglas Y. Mah (Boston Children's Hospital)H-Index: 14
#2Lynn A. Sleeper (Boston Children's Hospital)H-Index: 69
Last.Elif Seda Selamet Tierney (Boston Children's Hospital)H-Index: 17
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#1Elif Seda Selamet Tierney (Boston Children's Hospital)H-Index: 17
#2Jami C. Levine (Boston Children's Hospital)H-Index: 22
Last.De Backer J (Ghent University Hospital)H-Index: 39
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#1John Dean (ARI: Aberdeen Royal Infirmary)H-Index: 11
#2Bart LoeysH-Index: 56
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