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American Heart Journal
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4.02
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Papers 29614
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Background Administrative data were used to investigate changes in hospitalizations for atrial fibrillation (AF), AF-related stroke, and treatment patterns between 2012 and 2016. Methods From the ‘Ricerca e Salute’ database, a population- and patient-based repository involving >12 million inhabitants and linking demographics, prescriptions, and hospital discharge records, all patients discharged alive with a diagnosis of AF between 2012 and 2015 were followed for 1 year. Results A total of 194,0...
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Background Optimal ablation technique, including catheter-tissue contact during atrial fibrillation (AF) radiofrequency (RF) ablation is associated with improved procedural outcomes. We used a custom developed software to analyze high frequency catheter position data to study the interaction between catheter excursion during lesion placement, lesion-set sequentiality and arrhythmia recurrence. Methods 100 consecutive patients undergoing first time RF ablation for paroxysmal AF were analyzed. Spa...
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Objectives To compare outcomes of catheter ablation in patients with persistent atrial fibrillation (AF) undergoing pulmonary vein isolation (PVI) with and without adjunctive posterior wall isolation (PWI). Background PWI is increasingly used as an adjunctive lesion set to compliment PVI, especially in patients with persistent AF. Methods We performed a retrospective study of 558 patients who underwent de novo and repeat ablation for persistent AF. Subjects were matched using propensity score ad...
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Self-report of health conditions and behaviors is one potential strategy to increase the pace of enrollment into pragmatic clinical trials. In this study, we assessed the accuracy of self-reported poorly-controlled hypertension among adults in the community who were screened for participation in the MedISAFE-BP trial. Of individuals who self-reported poorly-controlled hypertension using the online trial enrollment platform, 64% had a systolic blood pressure less than 140 mmHg when measured at ho...
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#1Adam D. DeVore (Duke University)H-Index: 20
#2Bradi B. Granger (Duke University)H-Index: 20
Last.Adrian F. Hernandez (Duke University)H-Index: 81
view all 23 authors...
Abstract Many therapies have been shown to improve outcomes for patients with heart failure (HF) in controlled settings, but there are limited data available to inform best practices for hospital and post-discharge quality improvement initiatives. The CONNECT-HF (Care Optimization Through Patient and Hospital Engagement Clinical Trial for HF) study is a prospective, cluster-randomized trial of 161 hospitals in the United States with a 2x2 factorial design. The study is designed to assess the eff...
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#1M. T. Barrio (Grupo México)H-Index: 2
#2Miguel Ruiz-Canela (University of Navarra)H-Index: 27
Last.Almendral Garrote J (Grupo México)H-Index: 34
view all 12 authors...
Abstract Background Atrial fibrillation (AF) is the most common cardiac arrhythmia. Catheter ablation aims to restore sinus rhythm. However, relapses occur in up to 30% of patients. A Mediterranean diet (MedDiet) enriched with extra-virgin olive oil (EVOO) substantially reduced the incidence of AF in the PREDIMED trial. The “PREvention of Recurrent Arrhythmias with Mediterranean Diet” (PREDIMAR) will test a similar intervention in secondary prevention. Methods PREDIMAR is a multicentre, randomiz...
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Background Rates and predictors of major bleeding in patients with peripheral artery disease (PAD) treated with antiplatelets have not been well studied. This post hoc analysis of EUCLID aimed to determine the incidence of major/minor bleeding, predictors of major bleeding, and risk of major adverse cardiovascular events (MACE) following major bleeding events. Methods EUCLID, a multicenter randomized controlled trial of 13,885 patients with symptomatic PAD, compared ticagrelor with clopidogrel f...
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Abstract Objectives To explore associations between spontaneous reperfusion (SR) in ST-segment elevation myocardial infarction (STEMI) using a multi-marker cardiovascular proteins strategy. Background Although SR prior to primary percutaneous coronary intervention (pPCI) is associated with improved outcomes, its pathophysiology remains unclear. Methods We evaluated STEMI patients from the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX AMI) trial treated with pPCI within 6 hours f...
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Abstract Background Cardiogenic syncope in Brugada syndrome (BrS) increases the risk of major events. Nevertheless, clinical differentiation between cardiogenic and vasovagal syncope can be challenging. We characterized the long-term incidence of major events in a large cohort of BrS patients presented with syncope. Methods From a total of 474 patients, syncope was the initial manifestation in 135 (28.5%) individuals (43.9 ± 13.9 years, 71.1% male). The syncope was classified prospectively in ca...
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Aims Cardiorespiratory fitness (CRF) is closely linked to health status and clinical outcomes in heart failure (HF) patients. We aimed to test whether biomarkers can reflect CRF and its change over time. Methods and Results This post-hoc analysis utilized data from ambulatory cohorts of heart failure with reduced ejection fraction (HFrEF) (IRONOUT) and heart failure with preserved ejection fraction (HFpEF) (RELAX). Cardiopulmonary exercise testing, 6 minute walk distance (6MWD), and serum biomar...
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