Original paper
Quantitative Chemical Proteomics for Identifying Candidate Drug Targets
Abstract
We have developed a systematic strategy for drug target identification. This consists of the following sequential steps: (1) enrichment of total binding proteins using two differential affinity matrixes upon which are immobilized positive and negative chemical structures for drug activity, respectively; (2) covalent labeling of the proteins with a new cleavable isotope-coded affinity tag (ICAT) reagent, followed by proteolysis of the combined...
Paper Details
Title
Quantitative Chemical Proteomics for Identifying Candidate Drug Targets
Published Date
Apr 3, 2003
Journal
Volume
75
Issue
9
Pages
2159 - 2165
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Notes
History