The Potent Somatostatin Analogue Vapreotide Does Not Decrease Pancreas-Specific Complications After Elective Pancreatectomy: A Prospective, Multicenter, Double-Blinded, Randomized, Placebo-Controlled Trial

Pancreatectomy can be complicated by pancreatic anastomotic leakage, causing major morbidity.Our aim was to determine if vapreotide, a potent long-acting somatostatin analogue, would decrease pancreas-related complications. This prospective, multicenter, randomized, double-blind, placebo-controlled trial involved 275 patients without preexisting chronic pancreatitis undergoing elective proximal, central, or distal pancreatectomy. Complications...