M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7
Volume: 111, Issue: 13
Published: Mar 17, 2014
Abstract
Significance Here, we show how, mechanistically, inflammation-recruited macrophages may stimulate beta-cell proliferation in the pancreas, and specifically identify that TGFβ1 and EGF, which are secreted by M2 macrophages, induce SMAD7 expression in beta cells. SMAD7 not only activates cell cycle activators but also induces the nuclear exclusion of cell cycle inhibitors to promote beta-cell replication. Our study thus reveals a molecular pathway...
Paper Details
Title
M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7
Published Date
Mar 17, 2014
Volume
111
Issue
13
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