Propofol Decreases Myofilament Ca2+Sensitivity via a Protein Kinase C–, Nitric Oxide Synthase–dependent Pathway in Diabetic Cardiomyocytes

Background The authors' objective was to assess the role of protein kinase C (PKC) and nitric oxide synthase (NOS) in mediating the effects of propofol on diabetic cardiomyocyte contractility, intracellular free Ca2+ concentration ([Ca2+]i), and myofilament Ca2+ sensitivity. Methods Freshly isolated ventricular myocytes were obtained from normal and diabetic rat hearts. [Ca2+]i and cell shortening were simultaneously measured in electrically...