Recombinational DNA Repair Defects in Lung Cancer and PARP Inhibitor Sensitivity

Purpose/Objective(s)Homologous recombination repair (HRR) is important for removal of DNA damage caused by cisplatin, PARP inhibitors, and ionizing radiation (IR). HRR may be impaired by genetic, epigenetic, or other mechanisms in cancer, which makes it challenging to assess the functional HRR status in a given tumor. This presents an important barrier to individualization of therapy. We monitored the ability of non-small cell lung cancer...