Henning Willers
Harvard University
RadiologyLung cancerCancer researchRadiation therapyMedicine
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Publications 180
#1Thomas J. Roberts (Harvard University)H-Index: 39
Last. David P. RyanH-Index: 62
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Every year millions of pulmonary nodules are discovered incidentally and through lung cancer screening programs. Management of these nodules is often suboptimal, with low follow-up rates and poor provider understanding of management approaches. There is an emerging body of literature about how to optimize management of pulmonary nodules. The Pulmonary Nodule and Lung Cancer Screening Clinic (PNLCSC) at Massachusetts General Hospital was founded in 2012 to manage pulmonary nodules via a multidisc...
1 CitationsSource
#1Emily S. Lebow (Harvard University)
#2William L. Hwang (Harvard University)H-Index: 17
Last. Helen A. Shih (Harvard University)H-Index: 34
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PURPOSE: Cranial irradiation results in cognitive decline, which is hypothesized to be partially attributable to hippocampal injury and stem cell loss. Recent advances allow for targeted reduction of radiation dose to the hippocampi while maintaining adequate dose coverage to the brain parenchyma and additional increasing dose to brain metastases, a approach called hippocampal avoidance whole brain radiation therapy with a simultaneous integrated boost (HA-WBRT + SIB.) We review our early clinic...
#1Maria Lucia L. Madariaga (Harvard University)H-Index: 8
#2Inga T. Lennes (Harvard University)H-Index: 21
Last. Subba R. DigumarthyH-Index: 29
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Abstract Objective Pulmonary nodules found incidentally or by lung cancer screening differ in prevalence, risk profile and diagnostic intervention. The results of surgical intervention for incidental versus screening lung nodules during multidisciplinary Pulmonary Nodule and Lung Cancer Screening Clinic (PNLCSC) follow-up have not been reported. Methods All patients evaluated at a PNLCSC from 2012-2018 following referral by primary care physicians, specialist physicians or self-referral after co...
2 CitationsSource
#1L Aimee McNamara (Harvard University)H-Index: 1
#1L Aimee McNamara (Harvard University)H-Index: 1
Last. Harald PaganettiH-Index: 52
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Dose in proton radiotherapy is generally prescribed by scaling the physical proton dose by a constant value of 1.1. Relative biological effectiveness (RBE) is defined as the ratio of doses required...
2 CitationsSource
#1Justin F. GainorH-Index: 35
#2Sara StevensH-Index: 4
Last. Rebecca S. HeistH-Index: 42
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#1David M. McClatchy (Harvard University)H-Index: 7
#2Henning Willers (Harvard University)H-Index: 31
Last. Clemens Grassberger (Harvard University)H-Index: 13
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The optimal integration of molecularly targeted therapies with concurrent chemotherapy and radiation (CRT) to improve cures in genotype-defined cancers is unknown. Here, we develop a bio-mathematical framework to simulate patterns of local versus distant recurrences in a heterogeneous lung cancer population receiving combined targeted therapy and CRT. Our validated model predicts that targeted induction before CRT, an approach currently being tested in clinical trials, may render adjuvant target...
#1Henning Willers (Harvard University)H-Index: 31
#2Florence K. Keane (Harvard University)H-Index: 9
Last. Sophia C. Kamran (Harvard University)H-Index: 10
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#1Nikhil Sebastian (OSU: Ohio State University)H-Index: 5
#2T. Wu (OSU: Ohio State University)H-Index: 1
Last. Terence M. Williams (OSU: Ohio State University)H-Index: 32
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Abstract Background Tumor aggressiveness and hypoxia are linked to acidosis in the tumor microenvironment (TME). We hypothesized that low pre-treatment serum bicarbonate, potentially correlating with an acidic and hypoxic TME, predicts for poor outcomes after stereotactic body radiation therapy (SBRT) for non-small cell lung cancer (NSCLC). Methods We included patients with localized NSCLC treated to a biologically effective dose (BED) ≥ 100 Gy, with available pre-treatment bicarbonate values wi...
#1Andrew BangH-Index: 5
#2Umair MahmoodH-Index: 1
Last. Jonathan SchoenfeldH-Index: 18
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