Review paper
Telomere and telomerase in oncology
Abstract
Shortening of the telomeric DNA at the chromosome ends is presumed to limit the lifespan of human cells and elicit a signal for the onset of cellular senescence. To continually proliferate across the senescent checkpoint, cells must restore and preserve telomere length. This can be achieved by telomerase, which has the reverse transcriptase activity. Telomerase activity is negative in human normal somatic cells but can be detected in most tumor...
Paper Details
Title
Telomere and telomerase in oncology
Published Date
Mar 1, 2002
Journal
Volume
12
Issue
1
Pages
1 - 7
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