TSC1 controls macrophage polarization to prevent inflammatory disease
Abstract
Macrophages acquire distinct phenotypes during tissue stress and inflammatory responses, but the mechanisms that regulate the macrophage polarization are poorly defined. Here we show that tuberous sclerosis complex 1 (TSC1) is a critical regulator of M1 and M2 phenotypes of macrophages. Mice with myeloid-specific deletion of TSC1 exhibit enhanced M1 response and spontaneously develop M1-related inflammatory disorders. However, TSC1-deficient...
Paper Details
Title
TSC1 controls macrophage polarization to prevent inflammatory disease
Published Date
Sep 1, 2014
Journal
Volume
5
Issue
1
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