Organization and Lipid Interaction of the Model Amphipathic α-Helix Bundle Protein apoLp-III

Amphipathic α-helix bundle domains are found in many proteins responsible for neutral lipid transport and storage. Important examples are found in apoE, the perilipins, and the representative exchangeable apolipoprotein apoLp-III. Here we characterized the organization and lipid interaction of apoLp-III in Langmuir monolayers modeling the phospholipid monolayer surrounding the neutral lipid particle, i.e. lipoprotein. Surface-sensitive X-ray...