The NEIL glycosylases remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structures
Abstract
G-quadruplex is a four-stranded G-rich DNA structure that is highly susceptible to oxidation. Despite the important roles that G-quadruplexes play in telomere biology and gene transcription, neither the impact of guanine lesions on the stability of quadruplexes nor their repair are well understood. Here, we show that the oxidized guanine lesions 8-oxo-7,8-dihydroguanine (8-oxoG), guanidinohydantoin (Gh) and spiroiminodihydantoin (Sp) reduce the...
Paper Details
Title
The NEIL glycosylases remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structures
Published Date
Mar 26, 2015
Journal
Volume
43
Issue
8
Pages
4039 - 4054
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