Improvements in Bone Density and Structure during Anti-TNF-α Therapy in Pediatric Crohn's Disease

Pediatric Crohn's Disease (CD) is associated with deficits in trabecular bone mineral density (BMD) and cortical structure, potentially related to TNF-α effects to decrease bone formation and promote bone resorption.This study aimed to examine changes in bone density and structure in children and adolescents with CD following initiation of anti-TNF-α therapy.Participants (n = 74; age 5-21 years) with CD completed a 12-month prospective cohort...