Integrative genomics viewer

Published on Jan 1, 2011in Nature Biotechnology31.86
· DOI :10.1038/nbt.1754
James Robinson91
Estimated H-index: 91
(MIT: Massachusetts Institute of Technology),
Helga Thorvaldsdottir12
Estimated H-index: 12
(MIT: Massachusetts Institute of Technology)
+ 4 AuthorsJill P. Mesirov71
Estimated H-index: 71
(MIT: Massachusetts Institute of Technology)
Rapid improvements in sequencing and array-based platforms are resulting in a flood of diverse genome-wide data, including data from exome and whole-genome sequencing, epigenetic surveys, expression profiling of coding and noncoding RNAs, single nucleotide polymorphism (SNP) and copy number profiling, and functional assays. Analysis of these large, diverse data sets holds the promise of a more comprehensive understanding of the genome and its relation to human disease. Experienced and knowledgeable human review is an essential component of this process, complementing computational approaches. This calls for efficient and intuitive visualization tools able to scale to very large data sets and to flexibly integrate multiple data types, including clinical data. However, the sheer volume and scope of data pose a significant challenge to the development of such tools.
  • References (13)
  • Citations (3987)
#1D Altshuler (Broad Institute)H-Index: 177
#2Richard Durbin (Wellcome Trust Sanger Institute)H-Index: 103
Last.Michael Egholm (Pall Corporation)H-Index: 68
view all 368 authors...
#1Marc Fiume (U of T: University of Toronto)H-Index: 10
#2Vanessa Williams (U of T: University of Toronto)H-Index: 5
Last.Michael Brudno (U of T: University of Toronto)H-Index: 45
view all 4 authors...
#1Michael F. Berger (Broad Institute)H-Index: 71
#2Joshua Z. Levin (Broad Institute)H-Index: 36
Last.Carrie Sougnez (Broad Institute)H-Index: 69
view all 26 authors...
#1Cydney B. NielsenH-Index: 18
#2Michael N. CantorH-Index: 6
Last.Ting Wang (WashU: Washington University in St. Louis)H-Index: 36
view all 5 authors...
#1Iain Milne (SCRI: Scottish Crop Research Institute)H-Index: 16
#2Micha Bayer (SCRI: Scottish Crop Research Institute)H-Index: 19
Last.David Marshall (SCRI: Scottish Crop Research Institute)H-Index: 20
view all 7 authors...
#1John W. Nicol (UNCC: University of North Carolina at Charlotte)H-Index: 2
#2Gregg A. Helt (UNCC: University of North Carolina at Charlotte)H-Index: 1
Last.Ann E. Loraine (UNCC: University of North Carolina at Charlotte)H-Index: 24
view all 5 authors...
#1Hua Bao (SYSU: Sun Yat-sen University)H-Index: 11
#2Hui Guo (SYSU: Sun Yat-sen University)H-Index: 18
Last.Suhua Shi (SYSU: Sun Yat-sen University)H-Index: 29
view all 6 authors...
#1Mitchell Guttman (Broad Institute)H-Index: 36
#2Ido Amit (Broad Institute)H-Index: 51
Last.John P. Cassady (MIT: Massachusetts Institute of Technology)H-Index: 15
view all 20 authors...
#1Roger E. McLendon (Duke University)H-Index: 90
#2Allan H. Friedman (Duke University)H-Index: 87
Last.Kenneth Aldape (University of Texas MD Anderson Cancer Center)H-Index: 8
view all 231 authors...
Cited By3987
#1Alida Palmisano (NIH: National Institutes of Health)H-Index: 8
#2Julia Krushkal (NIH: National Institutes of Health)H-Index: 2
Last.Lisa M. McShane (NIH: National Institutes of Health)H-Index: 56
view all 9 authors...
#1Stefanie Dukowic-Schulze (UMN: University of Minnesota)H-Index: 10
#2Nelson Garcia (UMN: University of Minnesota)
Last.Chang-BinCHEN (UMN: University of Minnesota)H-Index: 17
view all 0 authors...
#1Xinyan Zhang (Purdue University)
#2Meixia Zhao (Purdue University)H-Index: 14
Last.Damon Lisch (Purdue University)H-Index: 32
view all 3 authors...
#1Brett W. Stringer (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 15
#2Bryan W. Day (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 16
Last.Seçkin Akgül (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 1
view all 22 authors...
#1Feiyang Ma (UCLA: University of California, Los Angeles)H-Index: 1
#2Brie K. Fuqua (UF: University of Florida)H-Index: 1
Last.Matteo Pellegrini (UCLA: University of California, Los Angeles)H-Index: 61
view all 7 authors...
#1Daryl M. Gohl (UMN: University of Minnesota)H-Index: 13
#2Alessandro Magli (UMN: University of Minnesota)H-Index: 10
Last.Shana L. McDevitt (UC: University of California)
view all 11 authors...
View next paperA method and server for predicting damaging missense mutations