Review paper
Telomerase Reverse Transcriptase Delays Aging in Cancer-Resistant Mice
Abstract
Telomerase confers limitless proliferative potential to most human cells through its ability to elongate telomeres, the natural ends of chromosomes, which otherwise would undergo progressive attrition and eventually compromise cell viability. However, the role of telomerase in organismal aging has remained unaddressed, in part because of the cancer-promoting activity of telomerase. To circumvent this problem, we have constitutively expressed...
Paper Details
Title
Telomerase Reverse Transcriptase Delays Aging in Cancer-Resistant Mice
Published Date
Nov 1, 2008
Journal
Volume
135
Issue
4
Pages
609 - 622
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