Original paper
Mitochondrial Gene Polymorphisms That Protect Mice From Colitis
Abstract
Dysregulated energy homeostasis in the intestinal mucosa frequently is observed in patients with ulcerative colitis (UC). Intestinal tissues from these patients have reduced activity of the mitochondrial oxidative phosphorylation (OXPHOS) complex, so mitochondrial dysfunction could contribute to the pathogenesis of UC. However, little is known about the mechanisms by which OXPHOS activity could be altered. We used conplastic mice, which have...
Paper Details
Title
Mitochondrial Gene Polymorphisms That Protect Mice From Colitis
Published Date
Nov 1, 2013
Journal
Volume
145
Issue
5
Pages
1055 - 1063.e3
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Notes
History