Oxidative stress in di-n-butyl-di-(4-chlorobenzohydroxamato)tin (IV)-induced hepatotoxicity determined by proteomic profiles

► Hepatotoxic mechanism induced by DBDCT was investigated using proteomics methods. ► Nine altered proteins associated with oxidative stress were identified. ► Up-regulated Trx1 may be a candidate biomarker for DBDCT-induced hepatotoxicity. ► DBDCT increased ROS and MDA expression while decreased GSH expression. ► Oxidative stress played a key role in DBDCT-induced hepatotoxicity. Significant attention has been paid to the antitumor...