Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner
Abstract
Age-dependent memory impairment is known to occur in several organisms, including Drosophila, mouse and human. However, the fundamental cellular mechanisms that underlie these impairments are still poorly understood, effectively hampering the development of pharmacological strategies to treat the condition. Polyamines are among the substances found to decrease with age in the human brain. We found that levels of polyamines (spermidine,...
Paper Details
Title
Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner
Published Date
Sep 1, 2013
Journal
Volume
16
Issue
10
Pages
1453 - 1460
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