Original paper
NuRD Blocks Reprogramming of Mouse Somatic Cells into Pluripotent Stem Cells
Abstract
Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) by overexpression of a defined set of transcription factors requires epigenetic changes in pluripotency genes. Nuclear reprogramming is an inefficient process and the molecular mechanisms that reset the epigenetic state during iPSC generation are largely unknown. Here, we show that downregulation of the nucleosome remodeling and deacetylation (NuRD) complex is required...
Paper Details
Title
NuRD Blocks Reprogramming of Mouse Somatic Cells into Pluripotent Stem Cells
Published Date
Jul 1, 2013
Journal
Volume
31
Issue
7
Pages
1278 - 1286
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Notes
History