A mouse model for glucocorticoid‐induced osteonecrosis: Effect of a steroid holiday

Glucocorticoid‐induced osteonecrosis is a common and dose‐limiting adverse event. The goal of this study was to establish a mouse model of glucocorticoid‐induced osteonecrosis suitable for testing the effects of different treatment strategies on its frequency. Fourteen murine strains were screened using various glucocorticoids, routes of administration, and diets. Four‐week‐old male BALB/cJ mice were treated with oral dexamethasone for up to 12...