Original paper
Buccal Permeation of Buspirone: Mechanistic Studies on Transport Pathways
Abstract
The transport of buspirone across porcine buccal mucosa in vitro was investigated to elucidate the mechanisms of transport and permeation enhancement. The apparent permeability increased with an increase in pH to a lesser degree than the dependence of the partition coefficient. Whereas the lipophilic or apparent transcellular pathway was found to be the dominant buccal transport route for buspirone, ionized species contributed significantly to...
Paper Details
Title
Buccal Permeation of Buspirone: Mechanistic Studies on Transport Pathways
Published Date
Jan 1, 2005
Volume
94
Issue
1
Pages
70 - 78
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Notes
History