Original paper
The PYRIN-CARD Protein ASC Is an Activating Adaptor for Caspase-1
Volume: 277, Issue: 24, Pages: 21119 - 21122
Published: Jun 1, 2002
Abstract
The PYRIN and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the apoptotic and inflammatory signaling pathways. Here we show that the PYRIN-CARD protein ASC functions as a caspase-1-activating adaptor. ASC interacted specifically with procaspase-1 via CARD-CARD interactions and induced its oligomerization. Consistent with these results ectopic expression of...
Paper Details
Title
The PYRIN-CARD Protein ASC Is an Activating Adaptor for Caspase-1
Published Date
Jun 1, 2002
Volume
277
Issue
24
Pages
21119 - 21122
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Notes
History