Original paper
Nuclear-Receptor-Mediated Telomere Insertion Leads to Genome Instability in ALT Cancers
Abstract
The breakage-fusion-bridge cycle is a classical mechanism of telomere-driven genome instability in which dysfunctional telomeres are fused to other chromosomal extremities, creating dicentric chromosomes that eventually break at mitosis. Here, we uncover a distinct pathway of telomere-driven genome instability, specifically occurring in cells that maintain telomeres with the alternative lengthening of telomeres mechanism. We show that, in these...
Paper Details
Title
Nuclear-Receptor-Mediated Telomere Insertion Leads to Genome Instability in ALT Cancers
Published Date
Feb 1, 2015
Journal
Volume
160
Issue
5
Pages
913 - 927
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Notes
History