Original paper

Maintenance of Metabolic Homeostasis by Sestrin2 and Sestrin3

Volume: 16, Issue: 3, Pages: 311 - 321
Published: Sep 1, 2012
Abstract
Chronic activation of mammalian target of rapamycin complex 1 (mTORC1) and p70 S6 kinase (S6K) in response to hypernutrition contributes to obesity-associated metabolic pathologies, including hepatosteatosis and insulin resistance. Sestrins are stress-inducible proteins that activate AMP-activated protein kinase (AMPK) and suppress mTORC1-S6K activity, but their role in mammalian physiology and metabolism has not been investigated. We show that...
Paper Details
Title
Maintenance of Metabolic Homeostasis by Sestrin2 and Sestrin3
Published Date
Sep 1, 2012
Volume
16
Issue
3
Pages
311 - 321
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