TET1 is a tumor suppressor of hematopoietic malignancy
Abstract
Methylation of DNA CpG motifs is modulated in part by the TET family of epigenetic regulators. Aifantis and colleagues show that loss of TET1 function biases hematopoiesis toward the B cell lineage and promotes hematopoietic malignancies. The methylcytosine dioxygenase TET1 (‘ten-eleven translocation 1’) is an important regulator of 5-hydroxymethylcytosine (5hmC) in embryonic stem cells. The diminished expression of TET proteins and loss of 5hmC...
Paper Details
Title
TET1 is a tumor suppressor of hematopoietic malignancy
Published Date
Apr 13, 2015
Journal
Volume
16
Issue
6
Pages
653 - 662
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History