Gene

Biology

Paragonimus westermani

Virology

Biochemistry

Immunology

Helminths

Antigen

Paragonimiasis

Microbiology

Paragonimus

Heterologous

Tropical Medicine & International Health

The specificity of three major polypeptides (35, 33 and 32.5 kD) from Paragonimus heterotremus antigens prepared from ether‐extracted adult worms was tested against sera from heterologous infections as well as against P. westermani ‐infected sera. Only the 35 kD polypeptide was not present, its antigenic determinant being bound to the antibodies from all P . westermani ‐infected cases. Its cross‐reactivity against various sera from heterologous helminthiases and other lung infections showed that it is not bound to these antigenic polypeptides. These major bands cannot be detected by Concanavalin A detector. Our research encourages the pattern (35, 33 and 32.5 kD) of immunoblot reactions for the diagnosis of P. heterotremus infections; the 35 kD antigen is specific for corresponding species and able to differentiate infections between both species of Paragonimus .

Human lung fluke Paragonimus heterotremus: differential diagnosis between Paragonimus heterotremus and Paragonimus westermani infections by EITB