Abstract 2853: Genetic variation in IGF1, GHR, and IGFBP1 is associated with colorectal cancer

Background The insulin-like growth factor (IGF-1)/growth hormone (GH) pathway has been implicated in the development of colorectal cancer. Circulating IGF-1 increases cell proliferation and inhibits apoptosis. Genetic variation in the IGF pathway genes has been shown to alter circulating IGF-1 concentrations and has been associated with colorectal cancer. This risk may differ by anatomic location. Methods We used a principal components approach...