Original paper

Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry

Volume: 102, Issue: 33, Pages: 11876 - 11881
Published: Aug 4, 2005
Abstract
Severe acute respiratory syndrome (SARS) is caused by an emergent coronavirus (SARS-CoV), for which there is currently no effective treatment. SARS-CoV mediates receptor binding and entry by its spike (S) glycoprotein, and infection is sensitive to lysosomotropic agents that perturb endosomal pH. We demonstrate here that the lysosomotropic-agent-mediated block to SARS-CoV infection is overcome by protease treatment of target-cell-associated...
Paper Details
Title
Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry
Published Date
Aug 4, 2005
Volume
102
Issue
33
Pages
11876 - 11881
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