TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4−8+ T cells
Abstract
The transporter associated with the antigen processing 1 (TAP1) gene encodes a subunit for a transporter, presumed to be involved in the delivery of peptides across the endoplasmic reticulum membrane to class I molecules. We have generated mice with a disrupted TAP1 gene using embryonic stem cell technology. TAP1-deficient mice are defective in the stable assembly and intracellular transport of class I molecules and consequently show severely...
Paper Details
Title
TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4−8+ T cells
Published Date
Dec 1, 1992
Journal
Volume
71
Issue
7
Pages
1205 - 1214
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Notes
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