Review paper

Yeast Gene for a Tyr-DNA Phosphodiesterase that Repairs Topoisomerase I Complexes

Science44.70
Volume: 286, Issue: 5439, Pages: 552 - 555
Published: Oct 15, 1999
Abstract
Covalent intermediates between topoisomerase I and DNA can become dead-end complexes that lead to cell death. Here, the isolation of the gene for an enzyme that can hydrolyze the bond between this protein and DNA is described. Enzyme-defective mutants of yeast are hypersensitive to treatments that increase the amount of covalent complexes, indicative of enzyme involvement in repair. The gene is conserved in eukaryotes and identifies a family of...
Paper Details
Title
Yeast Gene for a Tyr-DNA Phosphodiesterase that Repairs Topoisomerase I Complexes
Published Date
Oct 15, 1999
Journal
Volume
286
Issue
5439
Pages
552 - 555
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