Homocysteine and vascular disease: review of published results of the homocysteine‐lowering trials

Moderately elevated homocysteine levels have been associated with a higher risk of cardiovascular disease in observational studies, but whether these associations are causal is uncertain. Randomized trials of dietary supplementation with B vitamins were set up to assess whether lowering homocysteine levels could reduce the risk of vascular disease. This review is based on a meta‐analysis of published results of eight homocysteine‐lowering trials...