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GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases.

Published on Feb 1, 2015in Nature Biotechnology31.86
· DOI :10.1038/nbt.3117
Shengdar Q. Tsai25
Estimated H-index: 25
(Harvard University),
Zongli Zheng25
Estimated H-index: 25
+ 9 AuthorsJ. Keith Joung62
Estimated H-index: 62
(Harvard University)
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Abstract
An unbiased approach for the genome-wide detection of off-target cleavage by CRISPR-Cas9 RNA–guided nucleases reveals wide variability in the off-target activity of different guide RNAs.
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  • Citations (771)
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