Isolation of single-base genome-edited human iPS cells without antibiotic selection
Abstract
Precise editing of human genomes in pluripotent stem cells by homology-driven repair of targeted nuclease-induced cleavage has been hindered by the difficulty of isolating rare clones. We developed an efficient method to capture rare mutational events, enabling isolation of mutant lines with single-base substitutions without antibiotic selection. This method facilitates efficient induction or reversion of mutations associated with human disease...
Paper Details
Title
Isolation of single-base genome-edited human iPS cells without antibiotic selection
Published Date
Feb 9, 2014
Journal
Volume
11
Issue
3
Pages
291 - 293
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Notes
History