Review paper
Interleukin-6 and its receptors: A highly regulated and dynamic system
Abstract
Interleukin-6 (IL-6) is a multifunctional cytokine with well-defined pro- and anti-inflammatory properties. Although only small amounts in the picogram range can be detected in healthy humans, IL-6 expression is highly and transiently up-regulated in nearly all pathophysiological states. IL-6 induces intracellular signaling pathways after binding to its membrane-bound receptor (IL-6R), which is only expressed on hepatocytes and certain...
Paper Details
Title
Interleukin-6 and its receptors: A highly regulated and dynamic system
Published Date
Nov 1, 2014
Journal
Volume
70
Issue
1
Pages
11 - 20
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