Quality control mechanisms in cellular and systemic DNA damage responses
Abstract
The maintenance of the genome is of pivotal importance for the functional integrity of cells and tissues. The gradual accumulation of DNA damage is thought to contribute to the functional decline of tissues and organs with ageing. Defects in multiple genome maintenance systems cause human disorders characterized by cancer susceptibility, developmental failure, and premature ageing. The complex pathological consequences of genome instability are...
Paper Details
Title
Quality control mechanisms in cellular and systemic DNA damage responses
Published Date
Sep 1, 2015
Journal
Volume
23
Pages
3 - 11
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Notes
History