Cortical distribution of gangliosides in Alzheimer's disease
Abstract
In Alzheimer's disease, all ganglio-series gangliosides (GM1, GD1a, GD1b and GT1b) were found to be decreased in temporal and frontal cortex, and nucleus basalis of Meynert. In addition, in Alzheimer's disease simple gangliosides (GM2, GM3) were elevated in frontal and parietal cortex, possibly correlating to accelerated lysosomal degradation of gangliosides and/or astrogliosis occurring during neuronal...
Paper Details
Title
Cortical distribution of gangliosides in Alzheimer's disease
Published Date
Apr 1, 1992
Journal
Volume
20
Issue
3
Pages
433 - 438
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