Neutron Activation of NDDP, a Liposomal Platinum Antitumor Agent

Cis-bis-neodecanoato-trans-R,R-1,2-diamminocyclohexane platinum (II) [NDDP] is a liposome-entrapped platinum compound currently, in phase II clinical trials, that has been shown to undergo intraliposomal activation. The objective of this study was to determine the feasibility of activating NDDP and using the induced radioactivity to monitor NDDP distribution and penetration.Neutron activation analysis (NAA) was done on NDDP using the nuclear...