Match!
Donald S. Maclean
University of Kansas
3Publications
3H-index
64Citations
Publications 3
Newest
#1Donald S. Maclean (KU: University of Kansas)H-Index: 3
#2Quansheng Qian (KU: University of Kansas)H-Index: 1
Last.C. Russell Middaugh (KU: University of Kansas)H-Index: 50
view all 3 authors...
Abstract A method is described to identify small molecule ligands that stabilize proteins. The procedure is based on the hypothesis that molecules of various sizes containing two to four charges should occasionally bind to unpaired charged sites on the surface of proteins and by crosslinking such residues stabilize the native state of the liganded protein. A simple turbidity assay is employed that detects inhibition of protein aggregation under selected sets of conditions. Eight test proteins we...
50 CitationsSource
#1Donald S. Maclean (KU: University of Kansas)H-Index: 3
#2Abdul R. Khokhar (University of Texas MD Anderson Cancer Center)H-Index: 27
Last.Roman Perez-Soler (NYU: New York University)H-Index: 51
view all 3 authors...
Cis-bis-neodecanoato-trans-R,R-1,2-diamminocyclohexane platinum (II) [NDDP] is a liposome-entrapped platinum compound currently, in phase II clinical trials, that has been shown to undergo intraliposomal activation. The objective of this study was to determine the feasibility of activating NDDP and using the induced radioactivity to monitor NDDP distribution and penetration. Methods: Neutron activation analysis (NAA) was done on NDDP using the nuclear reactor at Texas A & M University, College S...
4 CitationsSource
#1Donald S. MacleanH-Index: 3
#2Abdul R. Khokhar (University of Texas MD Anderson Cancer Center)H-Index: 27
Last.Roman Perez-Soler (NYU: New York University)H-Index: 51
view all 4 authors...
L-NDDP is a liposome-entrapped platinum compound currently in phase 2 clinical trials that has been shown to undergo intraliposomal activation. The degradation/activation kinetics of liposome entrapped cis-bis-neodecanoatotrans-R,R-1,2-diamminocyclohexane platinum (II) [L-NDDP] at different conditions of pH, and temperature is presented. Liposomes were reconstituted in a solution of 0.9% sodium chloride (NaCl) in water (pH 5) at room temperature (formulation conditions currently used in the ongo...
10 CitationsSource
1